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DNA repair protein XRCC2; X-ray repair cross-complementing protein 2 (XRCC2)

Function: - role in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations & deletions - the BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA & specifically to nicks in duplex DNA - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with RAD51D - part of a BCDX2 complex - part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 & XRCC3 - in the absence of DNA, XRCC2-RAD51D forms a multimeric ring structure - in the presence of single-stranded DNA, XRCC2-RAD51D forms a filamentous structure Structure: belongs to the recA family, RAD51 subfamily Compartment: nucleus

Related

X-ray repair, complementing defective, repair in Chinese hamster cells-2 (XRCC2) gene

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 280 aa MW = 32 kD MOTIF: Ser phosphorylation site {S247} Ser phosphorylation site {S249}

Database Correlations

OMIM 600375 UniProt O43543 Entrez Gene 7516 Kegg hsa:7516

References

  1. UniProt :accession O43543
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/xrcc2/

Component-of

BCDX2 complex