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DNA repair protein RAD51 homolog 4; R51H3; RAD51-like protein 3; TRAD (RAD51L3, RAD51D)
Function:
- role in homologous recombination repair pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
- component of the BCDX2 complex
- interacts with ZSWIM7
Structure: belongs to the recA family, RAD51 subfamily
Compartment: nucleus (probable)
Alternative splicing:
- named isoforms=8
- one or more isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- expressed in colon, prostate, spleen, testis, ovary, thymus & small intestine
- weakly expressed in leukocytes
Pathology:
- defects in RAD51D are a cause of susceptibility to familial breast-ovarian cancer type 4
General
DNA repair protein Rad51 homolog
human longevity protein
Properties
SIZE: entity length = 328 aa
MW = 35 kD
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 107-114
Database Correlations
OMIM 602954
UniProt O75771
Pfam PF00730
Entrez Gene 5892
Kegg hsa:5892
References
- UniProt :accession O75771
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad51l3/
Component-of
BCDX2 complex