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DNA repair protein RAD51 homolog 2; R51H2; RAD51-like protein 1; Rad51B (RAD51L1, RAD51B, REC2)
Function:
- role in homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
- may promote assembly of presynaptic RAD51 nucleoprotein filaments
- interacts with RAD51C
- the RAD51B-RAD51C dimer exhibits single-stranded DNA dependent ATPase activity
- component of BCDX2 complex
- part of a complex with RAD51C & RAD51A
Structure:
- belongs to the recA family, RAD51 subfamily
Compartment: nucleus (probable)
Alternative splicing: named isoforms=5
Expression: expressed in a wide range of tissues
Pathology:
- chromosomal translocation t(6;14)(p21;q23-24) involving RAD51L1 with HMGA1 is found in pulmonary chondroid hamartoma
- chromosomal translocation t(12;14)(q15;q23-24) involving RAD51L1 with HMGA2 is found in uterine leiomyoma
General
DNA repair protein Rad51 homolog
human longevity protein
Properties
SIZE: entity length = 384 aa
MW = 42 kD
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 108-115
breakpoint {252-253}
Database Correlations
OMIM correlations
UniProt O15315
Pfam PF08423
Entrez Gene 5890
Kegg hsa:5890
References
- UniProt :accession O15315
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad51l1/
Component-of
BCDX2 complex