NF-Y protein chain B {beta}; CAAT-box DNA-binding protein subunit B; CCAAT-binding transcription factor subunit A; CBF-A, (NFYB)

Function: - component of nuclear factor V - stimulates the transcription of various genes by recognizing & binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin & beta-actin genes - NF-YB & NF-YC must interact & dimerize for NF-YA association & DNA binding Structure: - can be divided into 3 domains: a) weakly conserved A domain b) highly conserved B domain thought to be involved in subunit interaction & DNA binding c) Glu-rich C domain belongs to the NFYB/HAP3 subunit family Compartment: nucleus

General

nuclear protein protein subunit

Properties

SIZE: entity length = 207 aa MW = 23 kD MOTIF: A {1-52} B {53-142} MOTIF: DNA-binding motif SITE: 59-65 SAD {86-97} C {143-207}

Database Correlations

OMIM 189904 UniProt P25208 Pfam PF00808 Kegg hsa:4801

References

UniProt :accession P25208