NF-Y protein chain A {alpha} (CAAT-box DNA-binding protein subunit A, CCAAT-binding transcription factor subunit B, CBF-B, NFYA)

Function: - component of nuclear factor V - stimulates the transcription of various genes by recognizing & binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin & beta-actin genes - NF-YB & NF-YC must interact & dimerize for NF-YA association & DNA binding Structure: belongs to the NFYA/HAP2 subunit family Compartment: nucleus Alternative splicing: named isoforms=2

General

nuclear protein protein subunit

Properties

SIZE: entity length = 347 aa MW = 37 kD MOTIF: glutamine-rich region {14-161} MOTIF: glutamine residue (SEVERAL) Subunit association domain (SAD) {266-282} DNA-binding motif SITE: 298-318

Database Correlations

OMIM correlations MORBIDMAP 116897 UniProt P23511 Pfam PF02045 Kegg hsa:4800

References

UniProt :accession P23511