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CD130; gp130; interleukin-6 receptor subunit beta; IL-6R-beta; interleukin-6 signal transducer; membrane glycoprotein 130; CDw130; oncostatin-M receptor alpha subunit (IL6ST)

Function: - signal-transducing molecule - signal transducing subunit of several cytokine receptors - receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 & BSF3 can utilize gp130 for initiating signal transduction - binds to IL6/IL6R (alpha chain) complex, resulting in formation of high-affinity IL6 binding sites, & transduces the signal - does not bind IL6 - may have a role in embryonic development (putative). - forms heterodimers composed of LIPR & IL6ST (type 1 OSM receptor) - also forms heterodimers composed of OSMR & IL6ST (type 2 OSM receptor) - phosphorylation of Ser-782 down-regulates cell surface expression Structure: - the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding - the box 1 motif is required for JAK interaction &/or activation - belongs to the type 1 cytokine receptor family, type 2 subfamily - contains 5 fibronectin F3 modules - contains 1 Ig-like C2-type domains (immunoglobulin-like) Compartment: - isoform 1: cell membrane - isoform 2: secreted Alternative splicing: named isoforms=2 Expression: - found in all the tissues & cell lines examined - expression not restricted to IL6 responsive cells Pathology: - isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA Note: - GP130 also maps to 130 kD leucine-rich protein

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein phosphoprotein protein subunit

Properties

SIZE: entity length = 918 aa MW = 104 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {26-120} MOTIF: cysteine residue {C28} MODIFICATION: cysteine residue {C54} N-glycosylation site {N43} cysteine residue {C48} MODIFICATION: cysteine residue {C103} cysteine residue {C54} MODIFICATION: cysteine residue {C28} N-glycosylation site {N83} cysteine residue {C103} MODIFICATION: cysteine residue {C48} fibronectin type III domain or F3 module {125-216} MOTIF: N-glycosylation site {N131} cysteine residue {C134} MODIFICATION: cysteine residue {C144} cysteine residue {C144} MODIFICATION: cysteine residue {C134} N-glycosylation site {N157} cysteine residue {C172} MODIFICATION: cysteine residue {C182} cysteine residue {C182} MODIFICATION: cysteine residue {C172} fibronectin type III domain or F3 module {222-321} MOTIF: N-glycosylation site {N227} WSXWS motif {310-314} fibronectin type III domain or F3 module {326-418} MOTIF: N-glycosylation site {N379} N-glycosylation site {N383} fibronectin type III domain or F3 module {423-514} MOTIF: cysteine residue {C458} MODIFICATION: cysteine residue {C466} cysteine residue {C466} MODIFICATION: cysteine residue {C458} fibronectin type III domain or F3 module {518-610} MOTIF: N-glycosylation site {N553} N-glycosylation site {N564} transmembrane domain {620-641} box1 motif SITE: 651-659 FOR-BINDING-OF: Janus kinase (JAK) Ser phosphorylation site {S667} serine-rich region {725-755} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S782} Ser phosphorylation site {S820} Ser phosphorylation site {S829}

Database Correlations

OMIM 600694 UniProt P40189 PFAM correlations Kegg hsa:3572

References

  1. UniProt :accession P40189
  2. Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: 1542794
  3. Taga T, Kishimoto T. Cytokine receptors and signal transduction. FASEB J. 1992 Dec;6(15):3387-96. Review. PMID: 1334470
  4. Hopkins SJ & Rothwell NJ Cytokines and the nervous system. I: Expression and recognition. TINS 18:83 1995 PMID: 7537419

Component-of

Oncostatin-M specific receptor