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signal recognition particle receptor subunit alpha; SR-alpha; docking protein alpha; DP-alpha (SRPR)
Function:
- in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to the endoplasmic reticulum membrane system
- associates with beta chain (SRPRB) to form the SRP receptor
Structure: belongs to the GTP-binding SRP family
Compartment:
- endoplasmic reticulum membrane
- peripheral membrane protein
- thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain
General
guanine nucleotide regulatory protein (GNRP)
phosphoprotein
protein subunit
Properties
SIZE: entity length = 638 aa
MW = 70 kD
MOTIF: Tyr phosphorylation site {Y261}
Ser phosphorylation site {S296}
Ser phosphorylation site {S297}
Ser phosphorylation site {S298}
GTP-binding site
SITE: 425-432
GTP-binding site
SITE: 520-524
GTP-binding site
SITE: 588-591
Database Correlations
OMIM 182180
UniProt P08240
PFAM correlations
Kegg hsa:6734
References
- UniProt :accession P08240
- Stryer Biochemistry WH Freeman & Co, New York,
1988 pg 770
Component-of
signal recognition peptide [SRP] receptor or docking protein