retrieval

1) ==> enzymatic reaction ENZYME: coagulation factor Va {EXTRACELLULAR_MATRIX} (factor Va heavy chain -[Ca+2] factor Va light chain -[Ca+2]) SUBSTRATE: prothrombin {PLASMA} PRODUCT: thrombin {PLASMA} (protein subunit protein subunit) peptide {PLASMA.1202} :CELL NULL 2) ==> enzymatic reaction ENZYME: coagulation factor Va {EXTRACELLULAR_MATRIX} (factor Va heavy chain -[Ca+2] factor Va light chain -[Ca+2]) SUBSTRATE: prothrombin {PLASMA} PRODUCT: thrombin {PLASMA} (protein subunit protein subunit) peptide {PLASMA.1202} :CELL NULL 3) ==> enzymatic reaction ENZYME: thrombin {PLASMA} (protein subunit protein subunit -[THBD]) SUBSTRATE: protein C {PLASMA} PRODUCT: protein C, activated {PLASMA_MEMBRANE} -[PROS1] peptide {PLASMA.1202} :CELL PLATELET 4) ==> enzymatic reaction ENZYME: protein C, activated {PLASMA_MEMBRANE} -[PROS1] SUBSTRATE: coagulation factor Va {PLASMA} (factor Va heavy chain -[Ca+2] factor Va light chain -[Ca+2]) PRODUCT: peptide 5) ==> enzymatic reaction ENZYME: protein C, activated {PLASMA_MEMBRANE} -[PROS1] SUBSTRATE: coagulation factor VIIIa {PLASMA} (coagulation factor VIII heavy chain -[Ca+2] coagulation factor VIII light chain -[Ca+2]) PRODUCT: peptide 6) ==> enzymatic reaction ENZYME: protein C, activated {PLASMA_MEMBRANE} -[PROS1] SUBSTRATE: molecular complex (coagulation factor VIII von Willebrand factor) PRODUCT: peptide peptide von Willebrand factor {plasma} 7) ==> enzymatic reaction ENZYME: protease SUBSTRATE: protein H2O PRODUCT: peptide trimethyllysine 8) ==> enzymatic reaction ENZYME: APP alpha-secretase SUBSTRATE: APP-751 {PLASMA_MEMBRANE} PRODUCT: protease nexin-2 {EXTRACELLULAR_COMPARTMENT} peptide {PLASMA_MEMBRANE.1680} :CELL NULL 9) ==> enzymatic reaction ENZYME: APP alpha-secretase SUBSTRATE: APP-770 {PLASMA_MEMBRANE} PRODUCT: protease nexin-2 {EXTRACELLULAR_COMPARTMENT} peptide {PLASMA_MEMBRANE.1680} :CELL NULL 10) ==> enzymatic reaction ENZYME: APP gamma-secretase (nicastrin presenilin-1 pen-2 protein Aph-1 protein) SUBSTRATE: APP C83 peptide fragment PRODUCT: peptide 11) ==> enzymatic reaction ENZYME: APP gamma-secretase (nicastrin presenilin-1 pen-2 protein Aph-1 protein) SUBSTRATE: APP C99 peptide fragment PRODUCT: A4 amyloid peptide {extracellular compartment} peptide :CELL NULL 12) ==> enzymatic reaction ENZYME: APP gamma-secretase (nicastrin presenilin-1 pen-2 protein Aph-1 protein) SUBSTRATE: Notch extracellular truncation PRODUCT: Notch1 intracellular domain peptide 13) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: PEST protein* -[Ca+2] PRODUCT: peptide 14) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: cAMP kinase {CYTOPLASM} Ca+2 PRODUCT: peptide 15) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: protein kinase C type-A* {PLASMA_MEMBRANE} -[DAG Zn+2] PRODUCT: protein kinase C type-A* {CYTOPLASM} -[DAG Zn+2] peptide {PLASMA_MEMBRANE.1680} 16) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: calpastatin {cytoplasm} PRODUCT: calpastatin {cytoplasm} peptide 17) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: phosphotransferase PRODUCT: peptide 18) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: Ca+2 ATPase of plasma membrane {PLASMA_MEMBRANE} PRODUCT: Ca+2 ATPase of plasma membrane {PLASMA_MEMBRANE} peptide :CELL ERYTHROCYTE 19) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: fodrin {PLASMA_MEMBRANE} (alpha-fodrin beta-fodrin) PRODUCT: calmodulin binding protein peptide 20) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: microtubule-associated protein tau {CYTOPLASM} -[ACETYL] PRODUCT: peptide 21) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: villin {CYTOPLASM} PRODUCT: peptide 22) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: myosin {CYTOPLASM} (myosin heavy chain myosin essential light chain myosin regulatory light chain) PRODUCT: peptide 23) ==> enzymatic reaction ENZYME: calpain {CYTOPLASM} (calpain catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: filamin {cytoplasm} PRODUCT: peptide 24) ==> enzymatic reaction ENZYME: calpain-1 {CYTOPLASM} (calpain-1 catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: microtubule-associated protein (MAP)* PRODUCT: peptide 25) ==> enzymatic reaction ENZYME: calpain-1 (calpain-1 catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: neurofilament medium polypeptide -[ACETYL] PRODUCT: peptide {CYTOPLASM.375680} :CELL NEURON 26) ==> enzymatic reaction ENZYME: calpain-1 (calpain-1 catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: neurofilament light polypeptide -[ACETYL] PRODUCT: peptide {CYTOPLASM.375693} :CELL NEURON 27) ==> enzymatic reaction ENZYME: calpain-1 {CYTOPLASM} (calpain-1 catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: spectrin {PLASMA_MEMBRANE} (spectrin alpha chain, erythrocyte beta-spectrin) PRODUCT: peptide 28) ==> enzymatic reaction ENZYME: calpain-1 (calpain-1 catalytic subunit -[Ca+2] calpain regulatory subunit) SUBSTRATE: fodrin (alpha-fodrin beta-fodrin) PRODUCT: peptide {INTRACELLULAR_COMPARTMENT.375708} :CELL NEURON 29) ==> enzymatic reaction ENZYME: carboxypeptidase-E {EXTRACELLULAR_COMPARTMENT} SUBSTRATE: somatostatin {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 30) ==> enzymatic reaction ENZYME: cathepsin-L1 {LYSOSOME} SUBSTRATE: leucine enkephalin {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 31) ==> enzymatic reaction ENZYME: clipsin {TISSUE} SUBSTRATE: amyloid precursor protein {TISSUE} PRODUCT: peptide {TISSUE.375763} peptide {TISSUE.375765} 32) ==> enzymatic reaction ENZYME: caspase-3 {CYTOPLASM} SUBSTRATE: poly ADP-ribose polymerase PRODUCT: peptide 33) ==> enzymatic reaction ENZYME: caspase-6 {CYTOPLASM} SUBSTRATE: poly ADP-ribose polymerase PRODUCT: peptide 34) ==> enzymatic reaction ENZYME: metallo endopeptidase {CELLULAR_MEMBRANE} SUBSTRATE: cholecystokinin {EXTRACELLULAR_COMPARTMENT} PRODUCT: peptide 35) ==> enzymatic reaction ENZYME: metallo endopeptidase {CELLULAR_MEMBRANE} SUBSTRATE: neurotensin/neuromedin N {CYTOPLASM.1134} PRODUCT: peptide 36) ==> enzymatic reaction ENZYME: metallo endopeptidase {CELLULAR_MEMBRANE} SUBSTRATE: somatostatin {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 37) ==> enzymatic reaction ENZYME: metallo endopeptidase {CELLULAR_MEMBRANE} SUBSTRATE: substance-P {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 38) ==> enzymatic reaction ENZYME: neprilysin {PLASMA_MEMBRANE} SUBSTRATE: cholecystokinin {EXTRACELLULAR_COMPARTMENT} PRODUCT: peptide 39) ==> enzymatic reaction ENZYME: neprilysin {PLASMA_MEMBRANE} SUBSTRATE: neurotensin/neuromedin N {CYTOPLASM.1134} PRODUCT: peptide 40) ==> enzymatic reaction ENZYME: neprilysin {PLASMA_MEMBRANE} SUBSTRATE: somatostatin {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 41) ==> enzymatic reaction ENZYME: neprilysin {PLASMA_MEMBRANE} SUBSTRATE: substance-P {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide 42) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: fibronectin {plasma membrane} {blood} PRODUCT: peptide 43) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: thrombospondin {PLASMA} PRODUCT: peptide 44) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: coagulation factor V {PLASMA} PRODUCT: peptide 45) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: coagulation factor VIII {PLASMA} PRODUCT: peptide 46) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: platelet glycoprotein 1b {PLASMA_MEMBRANE} (platelet glycoprotein Ib alpha chain platelet glycoprotein Ib beta chain) PRODUCT: peptide {PLASMA.1202} peptide {PLASMA_MEMBRANE.376162} :CELL NULL 47) ==> enzymatic reaction ENZYME: plasmin {PLASMA} SUBSTRATE: TGF-beta {extracellular compartment} PRODUCT: TGF-beta {extracellular compartment} peptide :CELL NULL 48) ==> enzymatic reaction ENZYME: protease {LYSOSOME} SUBSTRATE: amyloid precursor protein-PHOSPHATE {LYSOSOME} PRODUCT: peptide {LYSOSOME.6304} 49) ==> enzymatic reaction ENZYME: protease {CYTOPLASM} SUBSTRATE: molecular complex {CYTOPLASM} (nuclear factor kappa-B (NF-kappa B) (NF-kappa B p50 subunit NF-kappa B p65) IKB-alpha-PHOSPHATE) PRODUCT: nuclear factor kappa-B (NF-kappa B) {CYTOPLASM} (NF-kappa B p50 subunit NF-kappa B p65) peptide {CYTOPLASM.1134} 50) ==> enzymatic reaction ENZYME: trypsin-like serine protease SUBSTRATE: somatostatin {EXTRACELLULAR_COMPARTMENT.1665} PRODUCT: peptide