retrieval

1) ==> chemical reaction SUBSTRATE: A4 amyloid peptide {cerebrospinal fluid} apo e3 {CEREBROSPINAL_FLUID} O2 PRODUCT: molecular complex {CEREBROSPINAL_FLUID} (A4 amyloid peptide apo e3) :CELL NULL 2) ==> chemical reaction SUBSTRATE: A4 amyloid peptide {cerebrospinal fluid} apo e4 {CEREBROSPINAL_FLUID} O2 PRODUCT: molecular complex {CEREBROSPINAL_FLUID} (A4 amyloid peptide apo e4) :CELL NULL 3) ==> chemical reaction SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} :CELL NULL 4) ==> enzymatic reaction ENZYME: cytochrome c oxidase {INNER_MITOCHONDRIAL_MEMBRANE} (cytochrome a cytochrome a3 cytochrome c oxidase subunit 1 cytochrome c oxidase subunit 2 cytochrome c oxidase subunit 3 cytochrome c oxidase subunit 4 isoform 1, mitochondrial cytochrome c oxidase subunit 5 cytochrome c oxidase subunit 6 cytochrome c oxidase subunit 7 cytochrome c oxidase subunit 8A, mitochondrial {MITOCHONDRIA} cytochrome c oxidase subunit 9 cytochrome c oxidase subunit 10) SUBSTRATE: H+ O2 {MITOCHONDRIA.1183} cytochrome c -[[]] PRODUCT: H+ H2O {MITOCHONDRIA.1183} cytochrome c -[[]] 5) ==> enzymatic reaction ENZYME: multienzyme complex {SMOOTH_ENDOPLASMIC_RETICULUM} (heme oxygenase-1 cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: heme {SMOOTH_ENDOPLASMIC_RETICULUM.367268} O2 NADPH PRODUCT: biliverdin {SMOOTH_ENDOPLASMIC_RETICULUM.367272} carbon monoxide NADP :CELL MACROPHAGE 6) ==> enzymatic reaction ENZYME: squalene epoxidase {SMOOTH_ENDOPLASMIC_RETICULUM} -[NADPH] SUBSTRATE: squalene NADPH O2 PRODUCT: squalene epoxide NAD H2O 7) ==> enzymatic reaction ENZYME: squalene oxidocyclase {SMOOTH_ENDOPLASMIC_RETICULUM} (squalene epoxidase -[NADPH] lanosterol cyclase -[NADPH]) SUBSTRATE: squalene NADPH O2 PRODUCT: lanosterol NAD H2O 8) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: dopamine O2 H2O PRODUCT: 3,4-dihydroxy-phenylacetate hydrogen peroxide NH3 9) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: 3-methoxydopamine O2 H2O PRODUCT: homovanillate hydrogen peroxide NH3 10) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: norepinephrine O2 H2O PRODUCT: 3,4-dihydroxymandellic acid hydrogen peroxide NH3 11) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: normetanephrine O2 H2O PRODUCT: vanillylmandelate methoxyhydroxyphenylglycol hydrogen peroxide NH3 12) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: epinephrine O2 H2O PRODUCT: 3,4-dihydroxymandellic acid hydrogen peroxide NH3 13) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: metanephrine O2 H2O PRODUCT: vanillylmandelate methoxyhydroxyphenylglycol hydrogen peroxide NH3 14) ==> enzymatic reaction ENZYME: prostaglandin [PG] synthase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: 8,11,14-eicosatrienoate {MEMBRANE.1676} O2 PRODUCT: prostaglandin G1 {MEMBRANE.1676} :CELL NULL 15) ==> enzymatic reaction ENZYME: 5-lipoxygenase {CYTOPLASM} SUBSTRATE: arachidonate {MEMBRANE.1676} O2 PRODUCT: 5-hydroperoxy-eicosatetraenoate {MEMBRANE.1676} :CELL NULL 16) ==> enzymatic reaction ENZYME: 12-lipoxygenase {CYTOPLASM} SUBSTRATE: arachidonate {MEMBRANE.1676} O2 PRODUCT: 12-hydroperoxy-eicosatetraenoate {MEMBRANE.1676} :CELL NULL 17) ==> enzymatic reaction ENZYME: 15-lipoxygenase {CYTOPLASM} SUBSTRATE: arachidonate {MEMBRANE.1676} O2 PRODUCT: 15-hydroperoxy-eicosatetraenoate {MEMBRANE.1676} :CELL NULL 18) ==> enzymatic reaction ENZYME: prostaglandin [PG] synthase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: arachidonate {MEMBRANE.1676} O2 PRODUCT: prostaglandin G2 {MEMBRANE.1676} :CELL NULL 19) ==> enzymatic reaction ENZYME: 5-lipoxygenase {CYTOPLASM} SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: 5-hydroperoxy-eicosapentaenoate {MEMBRANE.1676} :CELL NULL 20) ==> enzymatic reaction ENZYME: 12-lipoxygenase {CYTOPLASM} SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: 12-hydroperoxy-eicosapentaenoate {MEMBRANE.1676} :CELL NULL 21) ==> enzymatic reaction ENZYME: 15-lipoxygenase {CYTOPLASM} SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: 15-hydroperoxy-eicosapentaenoate {MEMBRANE.1676} :CELL NULL 22) ==> enzymatic reaction ENZYME: prostaglandin [PG] synthase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: prostaglandin G3 {MEMBRANE.1676} :CELL NULL 23) ==> enzymatic reaction ENZYME: multienzyme complex (cholesterol 20,22 desmolase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: cholesterol NADPH O2 PRODUCT: pregnenolone isocaproate {MEMBRANE.1676} NADP 24) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: pregnenolone O2 NADPH PRODUCT: 17-OH pregnenolone NADP 25) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-OH pregnenolone O2 NADPH PRODUCT: dehydroepiandrosterone NADP 26) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: progesterone O2 NADPH PRODUCT: 17-hydroxyprogesterone NADP 27) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-hydroxyprogesterone O2 NADPH PRODUCT: androstenedione NADP 28) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-21-hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: progesterone O2 NADPH PRODUCT: 11-deoxycorticosterone NADP 29) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-21-hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-hydroxyprogesterone O2 NADPH PRODUCT: 11-deoxycortisol NADP 30) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: 11-deoxycorticosterone NADPH O2 PRODUCT: corticosterone NADP 31) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: 11-deoxycortisol NADPH O2 PRODUCT: cortisol NADP 32) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: corticosterone NADPH O2 PRODUCT: aldosterone NADP 33) ==> enzymatic reaction ENZYME: cytochrome P450 19A1 {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: testosterone NADPH O2 PRODUCT: estradiol NADP 34) ==> enzymatic reaction ENZYME: cytochrome P450 19A1 {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: androstenedione NADPH O2 PRODUCT: estrone NADP 35) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: tryptamine NADH H2O O2 PRODUCT: tryptophal NAD NH3 hydrogen peroxide 36) ==> enzymatic reaction ENZYME: tryptophan hydroxylase -[BH4] SUBSTRATE: tryptophan O2 NADPH PRODUCT: 5-hydroxytryptophan H2O NADP 37) ==> enzymatic reaction ENZYME: monoamine oxidase SUBSTRATE: serotonin NADH H2O O2 PRODUCT: 5-OH tryptophal NAD NH3 hydrogen peroxide 38) ==> enzymatic reaction ENZYME: indoleamine-2,3-dioxygenase {CYTOPLASM} SUBSTRATE: tryptophan O2 PRODUCT: N-formyl kynurenine 39) ==> enzymatic reaction ENZYME: tryptophan-2,3-dioxygenase {CYTOPLASM} SUBSTRATE: tryptophan {CYTOPLASM.368407} O2 PRODUCT: N-formyl kynurenine {CYTOPLASM.368410} :CELL HEPATOCYTE 40) ==> enzymatic reaction ENZYME: kynurenine 3-monooxygenase {MITOCHONDRIA} SUBSTRATE: kynurenine O2 NADPH PRODUCT: 3-hydroxykynurenine H2O NADP 41) ==> enzymatic reaction ENZYME: hydroxylase SUBSTRATE: anthranilate O2 NADPH PRODUCT: 3-hydroxyanthranilate H2O NADP 42) ==> enzymatic reaction ENZYME: 3-OH anthranilate oxygenase {CYTOPLASM} SUBSTRATE: 3-hydroxyanthranilate O2 PRODUCT: 2-acroleyl-3-amino fumarate 43) ==> enzymatic reaction ENZYME: trimethyllysine hydroxylase {MITOCHONDRIAL_MATRIX} SUBSTRATE: trimethyllysine alpha-ketoglutarate O2 PRODUCT: beta-OH trimethyllysine succinate {MITOCHONDRIAL_MATRIX.2612} CO2 44) ==> enzymatic reaction ENZYME: gamma-butyrobetaine hydroxylase {CYTOPLASM} SUBSTRATE: gamma-butyrobetaine alpha-ketoglutarate O2 PRODUCT: carnitine {INNER_MITOCHONDRIAL_MEMBRANE.3547} succinate {MITOCHONDRIAL_MATRIX.2612} CO2 45) ==> enzymatic reaction ENZYME: 3-OH anthranilate oxygenase {CYTOPLASM} SUBSTRATE: 3-hydroxyanthranilate O2 PRODUCT: quinolinate alpha-aminomuconic delta-semialdehyde 46) ==> enzymatic reaction ENZYME: multienzyme complex {SMOOTH_ENDOPLASMIC_RETICULUM} (heme oxygenase-2 cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: heme O2 NADPH PRODUCT: biliverdin carbon monoxide NADP 47) ==> enzymatic reaction ENZYME: steroid-6-hydroxylase SUBSTRATE: corticosterone {INTRACELLULAR_COMPARTMENT.376343} O2 PRODUCT: 6-OH corticosterone {INTRACELLULAR_COMPARTMENT.376346} :CELL A6_KIDNEY_EPITHELIAL_CELL 48) ==> enzymatic reaction ENZYME: steroid-6-hydroxylase SUBSTRATE: cortisol {INTRACELLULAR_COMPARTMENT.376353} O2 PRODUCT: 6-OH cortisol {INTRACELLULAR_COMPARTMENT.376356} :CELL A6_KIDNEY_EPITHELIAL_CELL 49) ==> enzymatic reaction ENZYME: xanthine oxidase {peroxisome} {cytoplasm} SUBSTRATE: hypoxanthine O2 H2O PRODUCT: xanthine hydrogen peroxide 50) ==> enzymatic reaction ENZYME: xanthine oxidase {peroxisome} {cytoplasm} SUBSTRATE: xanthine O2 H2O PRODUCT: urate {PLASMA.1202} {SERUM.1203} hydrogen peroxide 51) ==> enzymatic reaction ENZYME: inositol-trisphosphate 3-kinase C {CYTOPLASM} {CELL_NUCLEUS} SUBSTRATE: sarcosine O2 H2O PRODUCT: glycine formaldehyde hydrogen peroxide 52) ==> mediation CAUSE: chemical reaction SUBSTRATE: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} O2 PRODUCT: 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} :CELL NULL EFFECT: binding SUBSTRATE: peroxisome proliferator-activated receptor alpha {CELL_NUCLEUS} 5,8,11,14,17-eicosapentaenoic acid {MEMBRANE.1676} PRODUCT: peroxisome proliferator-activated receptor alpha {CELL_NUCLEUS} -[EPA]