retrieval

1) ==> enzymatic reaction ENZYME: glucose-6-phosphate 1-dehydrogenase SUBSTRATE: glucose-6-phosphate (Robison ester) NADP PRODUCT: 6-phospho gluconolactone NADPH 2) ==> enzymatic reaction ENZYME: 6-phosphogluconate dehydrogenase (PGD, PGDH, 6PGD) SUBSTRATE: 6-phosphogluconate NADP PRODUCT: ribulose-5-phosphate NADPH 3) ==> enzymatic reaction ENZYME: multienzyme complex {SMOOTH_ENDOPLASMIC_RETICULUM} (heme oxygenase-1 cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: heme {SMOOTH_ENDOPLASMIC_RETICULUM.367268} O2 NADPH PRODUCT: biliverdin {SMOOTH_ENDOPLASMIC_RETICULUM.367272} carbon monoxide NADP :CELL MACROPHAGE 4) ==> enzymatic reaction ENZYME: biliverdin reductase {SMOOTH_ENDOPLASMIC_RETICULUM} -[NADPH NADH] SUBSTRATE: biliverdin {SMOOTH_ENDOPLASMIC_RETICULUM.367278} NADPH PRODUCT: bilirubin {SMOOTH_ENDOPLASMIC_RETICULUM.367282} NADP :CELL MACROPHAGE 5) ==> enzymatic reaction ENZYME: HMG CoA reductase {PEROXISOME} {ENDOPLASMIC_RETICULUM} SUBSTRATE: hydroxymethylglutaryl CoA {CYTOPLASM.1134} NADPH {CYTOPLASM.1134} PRODUCT: mevalonate {CYTOPLASM.1134} NADP {CYTOPLASM.1134} 6) ==> enzymatic reaction ENZYME: squalene synthetase {SMOOTH_ENDOPLASMIC_RETICULUM} (prenyl transferase-alpha prenyl transferase-beta) SUBSTRATE: farnesyl pyrophosphate NADPH PRODUCT: squalene NAD H2P2O7= 7) ==> enzymatic reaction ENZYME: squalene epoxidase {SMOOTH_ENDOPLASMIC_RETICULUM} -[NADPH] SUBSTRATE: squalene NADPH O2 PRODUCT: squalene epoxide NAD H2O 8) ==> enzymatic reaction ENZYME: squalene oxidocyclase {SMOOTH_ENDOPLASMIC_RETICULUM} (squalene epoxidase -[NADPH] lanosterol cyclase -[NADPH]) SUBSTRATE: squalene NADPH O2 PRODUCT: lanosterol NAD H2O 9) ==> enzymatic reaction ENZYME: multienzyme complex (cholesterol 20,22 desmolase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: cholesterol NADPH O2 PRODUCT: pregnenolone isocaproate {MEMBRANE.1676} NADP 10) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: pregnenolone O2 NADPH PRODUCT: 17-OH pregnenolone NADP 11) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-OH pregnenolone O2 NADPH PRODUCT: dehydroepiandrosterone NADP 12) ==> enzymatic reaction ENZYME: 3-beta hydroxysteroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: pregnenolone NADP PRODUCT: progesterone NADPH 13) ==> enzymatic reaction ENZYME: 3-beta hydroxysteroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: 17-OH pregnenolone NADP PRODUCT: 17-hydroxyprogesterone NADPH 14) ==> enzymatic reaction ENZYME: 3-beta hydroxysteroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: dehydroepiandrosterone NADP PRODUCT: androstenedione NADPH 15) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: progesterone O2 NADPH PRODUCT: 17-hydroxyprogesterone NADP 16) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-17-alpha hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-hydroxyprogesterone O2 NADPH PRODUCT: androstenedione NADP 17) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-21-hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: progesterone O2 NADPH PRODUCT: 11-deoxycorticosterone NADP 18) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-21-hydroxylase cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: 17-hydroxyprogesterone O2 NADPH PRODUCT: 11-deoxycortisol NADP 19) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: 11-deoxycorticosterone NADPH O2 PRODUCT: corticosterone NADP 20) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: 11-deoxycortisol NADPH O2 PRODUCT: cortisol NADP 21) ==> enzymatic reaction ENZYME: multienzyme complex (steroid-11-beta hydroxylase adrenodoxin, mitochondrial adrenodoxin reductase -[FAD NADP NADP NADP]) SUBSTRATE: corticosterone NADPH O2 PRODUCT: aldosterone NADP 22) ==> enzymatic reaction ENZYME: 17-hydroxysteroid dehydrogenase or 17-beta keto steroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: androstenedione NADPH PRODUCT: testosterone NADP 23) ==> enzymatic reaction ENZYME: cytochrome P450 19A1 {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: testosterone NADPH O2 PRODUCT: estradiol NADP 24) ==> enzymatic reaction ENZYME: cytochrome P450 19A1 {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: androstenedione NADPH O2 PRODUCT: estrone NADP 25) ==> enzymatic reaction ENZYME: 17-hydroxysteroid dehydrogenase or 17-beta keto steroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: estradiol NADP PRODUCT: estrone NADPH 26) ==> enzymatic reaction ENZYME: 17-hydroxysteroid dehydrogenase or 17-beta keto steroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: dehydroepiandrosterone NADPH PRODUCT: androstenediol NADP 27) ==> enzymatic reaction ENZYME: 3-beta hydroxysteroid dehydrogenase {SMOOTH_ENDOPLASMIC_RETICULUM} SUBSTRATE: androstenediol NADP PRODUCT: testosterone NADPH 28) ==> enzymatic reaction ENZYME: tryptophan hydroxylase -[BH4] SUBSTRATE: tryptophan O2 NADPH PRODUCT: 5-hydroxytryptophan H2O NADP 29) ==> enzymatic reaction ENZYME: kynurenine 3-monooxygenase {MITOCHONDRIA} SUBSTRATE: kynurenine O2 NADPH PRODUCT: 3-hydroxykynurenine H2O NADP 30) ==> enzymatic reaction ENZYME: hydroxylase SUBSTRATE: anthranilate O2 NADPH PRODUCT: 3-hydroxyanthranilate H2O NADP 31) ==> enzymatic reaction ENZYME: 5,10-methylenetetrahydrofolate reductase SUBSTRATE: N5,N10-methylenetetrahydrofolate NADPH PRODUCT: N5-methyltetrahydrofolate NAD 32) ==> enzymatic reaction ENZYME: dihydrofolate reductase (DHFR) SUBSTRATE: dihydrofolate NADPH H+ PRODUCT: tetrahydrofolate NADP 33) ==> enzymatic reaction ENZYME: amine oxidoreductase SUBSTRATE: folate NADPH H+ PRODUCT: dihydrofolate NADP 34) ==> enzymatic reaction ENZYME: dehydrogenase SUBSTRATE: N5,N10-methylenetetrahydrofolate NADP PRODUCT: N5,N10-methenyltetrahydrofolate NADPH H+ 35) ==> enzymatic reaction ENZYME: glutamate dehydrogenase {mitochondria} SUBSTRATE: glutamate NADP H2O PRODUCT: alpha-ketoglutarate NADPH NH3 36) ==> enzymatic reaction ENZYME: multienzyme complex {SMOOTH_ENDOPLASMIC_RETICULUM} (heme oxygenase-2 cytochrome P450 reductase -[NADP NADP]) SUBSTRATE: heme O2 NADPH PRODUCT: biliverdin carbon monoxide NADP