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1) ==> enzymatic reaction ENZYME: guanine nucleotide exchange factor SUBSTRATE: eukaryotic initiation factor 2 {CYTOPLASM} (eIF2-alpha -[GDP] eIF2-beta) guanosine triphosphate PRODUCT: eukaryotic initiation factor 2 {CYTOPLASM} (eIF2-alpha -[GTP] eIF2-beta) guanosine diphosphate 2) ==> enzymatic reaction ENZYME: guanine nucleotide exchange factor SUBSTRATE: elongation factor 2 {CYTOPLASM} -[GDP GTP] guanosine triphosphate PRODUCT: elongation factor 2 {CYTOPLASM} -[GTP] guanosine diphosphate 3) ==> enzymatic reaction ENZYME: guanine nucleotide exchange factor {PLASMA_MEMBRANE} SUBSTRATE: ras proto-oncogene protein (p21ras) {PLASMA_MEMBRANE} -[FARNESYL GDP] guanosine triphosphate PRODUCT: ras proto-oncogene protein (p21ras) {PLASMA_MEMBRANE} -[FARNESYL GTP] guanosine diphosphate :CELL T_LYMPHOCYTE 4) ==> enzymatic reaction ENZYME: guanine nucleotide exchange factor SUBSTRATE: ras subfamily protein {PLASMA_MEMBRANE} -[FARNESYL GDP] guanosine triphosphate PRODUCT: ras subfamily protein {PLASMA_MEMBRANE} -[FARNESYL GTP] guanosine diphosphate