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ZW10 interactor; ZW10-interacting protein 1; Zwint-1 (ZWINT)
Function:
- component of the MIS12 complex
- interacts with MIS12
- required to target ZW10 to the kinetochore at prometaphase
- interacts with KNTC2 subunit of the NDC80 complex specifically during mitosis
- interacts with CASC5, CETN3, DSN1 & PMF1
Compartment:
- nucleus, kinetochore
- localizes to kinetochores from late prophase to anaphase
Related
centromere/kinetochore protein zw10 homolog (ZW10)
M-phase phosphoprotein 5 (antisense ZW10 interactor, ZWINTAS)
General
human longevity protein
nuclear protein
Properties
SIZE: MW = 31 kD
entity length = 277 aa
COMPARTMENT: cell nucleus
MOTIF: ZW10 interaction {80-155}
coiled coil {104-217}
Database Correlations
OMIM 609177
UniProt O95229
Entrez Gene 11130
Kegg hsa:11130
References
- UniProt :accession O95229
- PMID: 15824131
- PMID: 824131