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zona pellucida sperm-binding protein 1 (zona pellucida glycoprotein 1, Zp-1, ZP1)
Function:
1) zona pellucida glycoprotein
2) ZP1 ensures structural integrity of zona pellucida
3) polymers of ZP2 & ZP3 organized into long filaments cross-linked by ZP1 homodimers
4) ZP domain is involved in the polymerization of ZP proteins to form the zona pellucida
5) proteolytically cleaved before transmembrane segment to yield secreted ectodomain incorporated in zona pellucida
Structure:
1) O-glycosylated
2) belongs to the ZP domain family, ZPB subfamily
3) contains 1 P-type domain (trefoil domain.
- contains 1 ZP domain
Compartment:
- cell membrane
- secreted, extracellular matrix upon proteolytic cleavage
Expression: expressed in oocytes
General
glycoprotein
membrane protein
secreted protein
Properties
SIZE: MW = 70 kD
entity length = 638 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
N-glycosylation site {N76}
P-type {234-277}
ZP domain {279-553}
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*2}
cysteine residue {*2}
MODIFICATION: cysteine residue {*1}
N-glycosylation site {N379}
cysteine residue {C457}
MODIFICATION: cysteine residue {C478}
cysteine residue {C478}
MODIFICATION: cysteine residue {C457}
N-glycosylation site {N561}
N-glycosylation site {N596}
transmembrane domain {602-622}
Database Correlations
OMIM 195000
UniProt P60852
Pfam PF00100
References
UniProt :accession P60852