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neuroblastoma suppressor of tumorigenicity 1; zinc finger protein DAN; N03; DAN domain family member 1 (NBL1, DAN, DAND1)
Function:
- may be tumor suppressor gene of neuroblastoma
- may play role in preventing cells from entering the final stage (G1/S) of the transformation process
Structure:
- belongs to the DAN family
- contains 1 CTCK domain (C-terminal cystine knot-like)
Compartment: secreted
Alternative splicing: named isoforms=2
Expression: most abundant in normal lung & meningioma
Pathology:
- defects in NBL1 may cause of &/or enhance progression of human neuroblastoma
General
secreted protein
zinc finger protein
Properties
SIZE: entity length = 180 aa
MW = 19 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
C-terminal cystine knot {34-123}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C84}
cysteine residue {C48}
MODIFICATION: cysteine residue {C98}
cysteine residue {C58}
MODIFICATION: cysteine residue {C117}
cysteine residue {C62}
MODIFICATION: cysteine residue {C119}
cysteine residue {C81}
MODIFICATION: cysteine residue {C122}
cysteine residue {C84}
MODIFICATION: cysteine residue {C34}
cysteine residue {C98}
MODIFICATION: cysteine residue {C48}
cysteine residue {C117}
MODIFICATION: cysteine residue {C58}
cysteine residue {C119}
MODIFICATION: cysteine residue {C62}
cysteine residue {C122}
MODIFICATION: cysteine residue {C81}
proline-rich region
SITE: 141-171
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 600613
UniProt P41271
Pfam PF03045
Entrez Gene 4681
Kegg hsa:4681
References
UniProt :accession P41271