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Zn+2 transporter ZIP8 (Zrt- & Irt-like protein 8, ZIP-8, solute carrier family 39 member 8, LIV-1 subfamily of ZIP Zn+2 transporter 6, LZT-Hs6, BCG-induced integral membrane protein in monocyte clone 103 protein, SLC39A8, BIGM103, ZIP8, PP3105)
Function: acts as a Zn+2-influx transporter
Structure: belongs to the ZIP transporter (TC 2.A.5) family
Compartment:
- membrane (putative)
- associated with the lysosomal/endosomal compartment following transfection
Alternative splicing: named isoforms=2
Expression:
- expressed in thymus, placenta, lung, liver, pancreas > spleen, testis, ovary, small intestine, colon, leukocyte, heart
- highest expression is observed in pancreas
- induced by live & heat-killed Mycobacterium bovis bacterial cell wall & inflammatory cytokines like TNFA
- down-regulated following phorbol ester treatment
General
glycoprotein
solute carrier family 39 (SLC39, SLC39A)
transmembrane 8e protein
Zn+2 transporter
Properties
SIZE: entity length = 460 aa
MW = 50 kD
COMPARTMENT: lysosome
endosome
MOTIF: exoplasmic domain {1-8}
transmembrane domain {9-29}
cytoplasmic loop {30-132}
transmembrane domain {133-153}
exoplasmic loop {154-160}
transmembrane domain {161-181}
cytoplasmic loop {182-191}
transmembrane domain {192-212}
exoplasmic loop {213-302}
MOTIF: N-glycosylation site {N273}
transmembrane domain {303-323}
cytoplasmic loop {324-365}
MOTIF: XEXPHE {343-348}
transmembrane domain {366-386}
exoplasmic loop {387-388}
transmembrane domain {389-409}
cytoplasmic loop {410-429}
transmembrane domain {430-450}
exoplasmic domain {451-460}
Database Correlations
OMIM 608732
UniProt Q9C0K1
Pfam PF02535
References
UniProt :accession Q9C0K1