Zn+2 finger RNA-binding protein (hZFR, M-phase phosphoprotein homolog, ZFR)

Function: - role in postimplantation & gastrulation stages of development - involved in the nucleocytoplasmic shuttling of STAU2 - binds to DNA & RNA (putative) - found in a cytoplasmic RNP complex with STAU2 - interacts with STAU2 - does not interact with STAU1 (putative) Structure: contains 1 DZF domain Compartment: - nucleus (putative), cytoplasm, cytoplasmic granule - associated with chromosome foci in meiotic cells - localizes in somatodendritic compartment of primary hippocampal neurons - colocalizes with STAU2 in several cytosolic RNA granules Expression: - expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain & kidney

General

nuclear protein phosphoprotein RNA-binding protein zinc finger protein

Properties

SIZE: entity length = 1074 aa MW = 117 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: alanine-rich region {36-302} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S476} DZF {790-1038} Ser phosphorylation site {S1054}

Database Correlations

UniProt Q96KR1 Pfam PF07528

References

UniProt :accession Q96KR1