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zinc toxicity
Etiology:
- chronic ingestion of pennies
- excessive zinc supplementation
- metal fume fever
Pathology:
- excessive zinc ingestion can suppress copper & iron absorption
- zinc intakes of as little as 150-450 mg/day may induce copper deficiency
Clinical manifestations:
- nausea/vomiting
- epigastric pain
- diarrhea
- headache
- fatigue, lethary
- ataxia
Laboratory:
- serum Zn+2
- complete blood count
- anemia
- neutropenia
- lipid panel: decreases in serum HDL cholesterol
Related
zinc deficiency
zinc [Zn]
Zn+2
Specific
metal fume fever
General
toxicity; poisoning; overdose
mineral overload
References
- Wikipedia: zinc toxicity
http://en.wikipedia.org/wiki/Zinc_toxicity
- Fosmire J
Zinc toxicity.
Am J Clin Nutr. 1990 Feb;51(2):225-7.
PMID: 2407097
- Zinc
Office of Dietary Supplements, National Institutes of Health
http://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/