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Zn+2 phosphodiesterase ELAC protein 2; elaC homolog protein 2; heredity prostate cancer protein 2; ribonuclease Z 2; Rnase Z 2; tRNA 3 endonuclease 2; tRnase Z 2 (ELAC2, HPC2)
Function:
- Zn+2 phosphodiesterase
- some tRNA 3'-processing endonuclease activity
- probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
- endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs
- a 3'-hydroxy group is left at the tRNA terminus & a 5'-phosphoryl group is left at the trailer molecule
Cofactor: Zn+2 (probable)
Structure:
- homodimer (putative)
- belongs to the Rnase Z family
Compartment: nucleus (probable)
Alternative splicing: named isoforms=3
Expression:
- widely expressed
- highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis & ovary
- weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon & leukocytes
Pathology:
- defects in ELAC2 may be a cause of susceptibility to prostate cancer
Related
prostate cancer
General
endoribonuclease
nuclear protein
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 826 aa
MW = 92 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S199}
Ser phosphorylation site {S208}
Database Correlations
OMIM correlations
MORBIDMAP 605367
UniProt Q9BQ52
Entrez Gene 60528
Kegg hsa:60528
ENZYME 3.1.26.11
References
- UniProt :accession Q9BQ52
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ELAC2ID40437ch17p11.html