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Zn+2 phosphodiesterase ELAC protein 1; deleted in Ma29; elaC homolog protein 1; ribonuclease Z 1; Rnase Z 1; tRNA 3 endonuclease 1; tRnase Z 1 (ELAC1, D29)
Function:
- Zn+2 phosphodiesterase
- some tRNA 3'-processing endonuclease activity
- probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
- endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs
- a 3'-hydroxy group is left at the tRNA terminus & a 5'-phosphoryl group is left at the trailer molecule
Cofactor: binds 2 Zn+2 (putative)
Structure:
- homodimer (putative)
- belongs to the Rnase Z family
Compartment: nucleus (probable)
Expression:
- widely expressed
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
General
endoribonuclease
nuclear protein
oligomerizing protein
Properties
SIZE: entity length = 363 aa
MW = 40 kD
COMPARTMENT: cell nucleus
MOTIF: Zn+2-binding site
SITE: 62-62
Zn+2-binding site
SITE: 64-64
aspartate residue {D66}
Zn+2-binding site
SITE: 66-66
Zn+2-binding site
SITE: 67-67
Zn+2-binding site
SITE: 182-182
Zn+2-binding site
SITE: 253-253
Zn+2-binding site
SITE: 313-313
Database Correlations
OMIM 608079
UniProt Q9H777
Entrez Gene 55520
Kegg hsa:55520
ENZYME 3.1.26.11
References
UniProt :accession Q9H777