zinc finger UBR1-type protein 1; retinoblastoma-associated factor of 600 kD; 600 kD retinoblastoma protein-associated factor; RBAF600; p600 (ZUBR1, KIAA0462, KIAA1307, RBAF600, UBR4)

Function: - together with clathrin, forms meshwork structures involved in membrane morphogenesis & cytoskeletal organization - regulates integrin-mediated signaling - role in activation of FAK in response to cell-matrix interactions (putative) - interacts with RB1 & calmodulin - interacts protein E7 from papilloma virus HPV-16, HPV-6B, HPV-11 Structure: - belongs to the ZUBR1 family - contains 1 UBR-type zinc finger Compartment: - membrane, cytoplasm, nucleus - concentrates at the leading edge of membrane structures involved in actin motility Alternative splicing: named isoforms=6

General

cytoskeletal protein membrane protein phosphoprotein zinc finger protein

Properties

SIZE: MW = 574 kD entity length = 5183 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: alanine-rich region {9-15} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S178} Ser phosphorylation site {S181} Ser phosphorylation site {S365} proline-rich region SITE: 608-631 MOTIF: proline residue (SEVERAL) transmembrane domain {850-870} transmembrane domain {993-1013} Zinc finger NAME: Zinc finger SITE: 1656-1729 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T2715} Ser phosphorylation site {S2719} Ser phosphorylation site {S2722} Thr phosphorylation site {T2724} serine-rich region {3339-3370} MOTIF: serine residue (SEVERAL)

Database Correlations

UniProt Q5T4S7 Pfam PF02207

References

UniProt :accession Q5T4S7