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zinc finger protein ZIC4; zinc finger protein of the cerebellum 4 (ZIC4)
Function:
- binds to DNA (putative)
Structure:
- belongs to the GLI C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus (putative)
Alternative splicing:
- named isoforms=2
- may be due to an intron retention
Laboratory:
- ZIC4 Ab in serum
Note:
- uncertain whether Met-1 is the initiator
General
nuclear protein
zinc finger protein of the cerebellum (ZIC)
Properties
SIZE: entity length = 334 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {23-27}
MOTIF: serine residue (SEVERAL)
alanine-rich region {88-94}
MOTIF: alanine residue (SEVERAL)
Zn finger C2H2-type
SITE: 128-162
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 171-198
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 204-228
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 234-258
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 264-288
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 608948
UniProt Q8N9L1
Pfam PF00096
Entrez Gene 84107
Kegg hsa:84107
References
UniProt :accession Q8N9L1