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zinc finger protein ubi-d4; apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4, Zn+2 & double PHD fingers family 2; protein requiem (DPF2, BAF45D, REQ, UBID4)
Function:
- may be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells
- might also have a role in the development & maturation of lymphoid cells
Structure:
- belongs to the requiem/DPF family
- contains 1 C2H2-type Zn+2 finger
- contains 2 PHD-type Zn+2 fingers
Compartment:
- nucleus, cytoplasm
- 30% nuclear, 70% cytoplasmic
Expression: ubiquitous
Related
apoptosis
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
pro apoptotic protein
Properties
SIZE: entity length = 391 aa
MW = 44 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S94}
Ser phosphorylation site {S97}
Ser phosphorylation site {S142}
Tyr phosphorylation site {Y172}
Thr phosphorylation site {T176}
Ser phosphorylation site {S200}
Zn finger C2H2-type
SITE: 209-232
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T248}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 270-330
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 327-377
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601671
UniProt Q92785
Pfam PF00628
Entrez Gene 5977
Kegg hsa:5977
References
- UniProt :accession Q92785
- NIEHS-SNPs
http://egp.gs.washington.edu/data/req/