zinc finger protein SNAI3 (protein snail homolog 3, zinc finger protein 293) (SNAI3 ZNF293)

Function: - seems to inhibit myoblast differentiation - transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes - binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' & 5'-CACCTG-3' Structure: - binds E-box via C2H2-type Zn⁺²-finger domain - belongs to the snail C2H2-type Zn⁺²-finger protein family - contains 5 C²H²-type Zn⁺²-fingers Compartment: nucleus (putative)

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 292 aa MW = 32 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 152-174 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 183-205 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 209-231 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 237-259 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 265-287 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q3KNW1 Pfam PF00096 Kegg hsa:3339

References

UniProt :accession Q3KNW1