zinc finger protein Rlf; rearranged L-myc fusion gene protein; Zn-15-related protein (RLF)

Function: - may be involved in transcriptional regulation - interacts with RIT1 & RIT2 (putative) Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 14 C2H2-type Zn⁺² fingers Compartment: nucleus (probable) Expression: - widely expressed in fetal & adult tissues Pathology: - in some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 (rearrangement 1p32 RLF with L-MYC) fusing the first exon of the RLF gene with L-myc

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 1914 aa MW = 218 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S41} Zn finger C2H2-type SITE: 582-604 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 671-696 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 714-736 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 742-766 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 771-795 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 801-825 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 954-979 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1127-1152 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1172-1195 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1310-1335 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1362-1387 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1407-1432 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1444-1469 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1549-1574 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 180610 UniProt Q13129 Entrez Gene 6018 Kegg hsa:6018

References

UniProt :accession Q13129