Search
zinc finger protein PLAGL1; lost on transformation 1; LOT-1; pleiomorphic adenoma-like protein 1; tumor supressor ZAC (PLAGL1, LOT1, ZAC)
Function:
- weak transcriptional activator
- transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide
- interacts with THRSP
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 7 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
General
C2H2 type zinc finger protein
nuclear protein
Properties
SIZE: entity length = 463 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 4-26
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 32-56
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 62-84
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 91-113
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 120-142
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 156-178
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 184-207
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 603044
UniProt Q9UM63
Entrez Gene 5325
Kegg hsa:5325
References
- UniProt :accession Q9UM63
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/PLAGL1
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PLAGL1ID41737ch6q24.html