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DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1 (IKZF1, IK1, IKAROS, LYF1, ZNFN1A1)
Function:
- binds & activates enhancer (delta-A element) of the CD3-delta gene
- role in specification & maturation of T-lymphocytes
- interacts with a control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B-cell & T-cell development
- interacts with IKZF4 & IKZF5
Structure:
- belongs to the Ikaros C2H2-type Zn+2-finger protein family
- contains 6 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=7
Expression:
- expressed in thymus, spleen, peripheral blood Leukocytes & lymph nodes > bone marrow & small intestine
General
ikaros family zinc finger protein
transcription factor (TF)
Properties
SIZE: entity length = 519 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 117-139
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 145-167
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 173-195
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 201-224
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 462-484
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 490-514
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 603023
UniProt Q13422
Pfam PF00096
Kegg hsa:1032
References
- UniProt :accession Q13422
- Kim et al. Immunity 10:345-355, 1999
- Entrez Gene :accession 10320
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/IkarosID258.html