zinc finger protein GLIS2 (GLI-similar 2, neuronal Krueppel-like protein, GLIS2, NKL)

Function: - role as transcription repressor or as transcription activator, depending on cell context - represses transcriptional activation mediated by CTNNB1 in Wnt pathway - recruits corepressors CTBP1 & HDAC3 - role in neuron differentiation - interacts with CTBP1 & HDAC3 - interacts with CTNNB1, CTNND1 - C-terminus cleavage is induced by interaction with CTNND1 & enhanced by Src tyrosine kinase Structure: - belongs to the GLI C2H2-type zinc-finger protein family. - contains 5 C2H2-type zinc fingers - C2H2-type zinc finger 1 has a major repressor function & is required for CTNNB1 binding Compartment: nuclear speckle, cytoplasm Expression: - expressed in kidney > heart, lung, placenta - expressed in colon

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 56 kD entity length = 524 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: interaction with CTNND1 {35-174} MOTIF: transcriptional activation domain SITE: 71-137 silencer element SITE: 148-171 Zn finger C2H2-type SITE: 168-193 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 202-229 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 235-257 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S245} Zn finger C2H2-type SITE: 263-287 EFFECTOR-BOUND: Zn+2 proteolytic site {287-288} Zn finger C2H2-type SITE: 293-317 EFFECTOR-BOUND: Zn+2 glycine-rich region {363-460}

Database Correlations

OMIM 608539 UniProt Q9BZE0 Pfam PF00096

References

UniProt :accession Q9BZE0