zinc finger protein 674 (ZNF674)

Function: - transcriptional regulation Structure: 1) belongs to the krueppel C2H2-type zinc-finger protein family 2) contains 11 C2H2-type zinc fingers 3) contains 1 KRAB domain Compartment: nucleus Expression: expressed in testis, fetal brain Pathology: - defects in ZNF674 may be the cause of nonsyndromic X-linked mental retardation (MRX92)

General

C2H2 type zinc finger protein DNA-binding protein

Properties

SIZE: MW = 67 kD entity length = 581 aa COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 8-79 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 224-246 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 252-274 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 280-302 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 308-330 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 385-407 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 413-435 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 441-463 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 469-491 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 497-519 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 525-547 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 553-575 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q2M3X9 PFAM correlations

References

UniProt :accession Q2M3X9