zinc finger protein AEBP2 (adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2)

Function: - DNA-binding transcriptional repressor - may interact with & stimulate activity of the PRC2 complex, which methylates Lys-9 & Lys-27 residues of histone H3 - self-associates - interacts with EED, EZH2, RBBP4 & SUZ12 - may also interact with RBBP7 Structure: - belongs to the AEBP2/jing C2H2-type Zn⁺²-finger family - contains 3 C2H2-type Zn⁺² fingers Compartment: nucleus (probable) Alternative splicing: named isoforms=3

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 517 aa MW = 54 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S18} Ser phosphorylation site {S24} Ser phosphorylation site {S27} glutamate-rich region {34-123} MOTIF: glutamate residue (SEVERAL) glycine-rich region {61-205} serine-rich region {110-256} MOTIF: serine residue (SEVERAL) RBBP4 interaction {209-294} MOTIF: Zn finger C2H2-type SITE: 261-286 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 300-322 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 328-352 EFFECTOR-BOUND: Zn+2 SUZ12 interaction {353-517}

Database Correlations

UniProt Q6ZN18 Pfam PF00096 Kegg hsa:1215

References

UniProt :accession Q6ZN18