zinc finger protein 85; zinc finger protein HPF4; HTF1 (ZNF85)

Function: - transcriptional repressor Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 16 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus Expression: - expressed preferentially in testicular tissues - expressed early during embryonic development

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 595 aa MW = 69 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 4-75 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 146-168 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 174-196 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 202-224 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 230-252 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 258-280 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 286-308 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 314-336 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 342-364 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 370-392 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 398-420 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 426-448 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 454-476 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 482-504 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 510-532 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 538-560 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 566-588 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 603899 UniProt Q03923 PFAM correlations Entrez Gene 7639 Kegg hsa:7639

References

UniProt :accession Q03923