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zinc finger protein 8; zinc finger protein HF.18 (ZNF8)
Function:
- may be involved in transcriptional regulation
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 7 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
Compartment: nucleus (probable)
Expression:
- ubiquitously present in many human cell lines of different embryological derivation
General
C2H2 type zinc finger protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 575 aa
MW = 65 kD
COMPARTMENT: cell nucleus
MOTIF: Krueppel-associated box
NAME: Krueppel-associated box
SITE: 25-96
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 257-279
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 285-307
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 313-335
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 341-363
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S355}
Zn finger C2H2-type
SITE: 369-391
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 397-419
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S455}
Zn finger C2H2-type
SITE: 467-489
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 194532
UniProt P17098
PFAM correlations
Entrez Gene 7554
References
UniProt :accession P17098