Search
zinc finger protein 741; Krueppel-like factor 8; basic Krueppel-like factor 3 (KLF8, BKLF3, ZNF741)
Function:
- transcriptional repressor & transcriptional activator
- binds to CACCC-box promoter elements
- also binds the GT-box of cyclin D1 promoter
- mediates cell cycle progression at G1 phase as a downstream target of focal adhesion kinase (FAK)
- sumoylation at Lys-67
- represses transcriptional activity & reduces cell cycle progression into the G1 phase
- no effect on subcellular location
- interacts with corepressor CtBP2
- interacts with PIAS1, PIAS2, & PIAS4;
- interaction with each ligase sumoylates KLF8
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: ubiquitous
General
C2H2 type zinc finger protein
Krueppel-like factor
nuclear protein
Properties
SIZE: entity length = 359 aa
MW = 39 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 274-298
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 304-328
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 334-356
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 300286
UniProt O95600
Entrez Gene 11279
Kegg hsa:11279
References
UniProt :accession O95600