zinc finger protein 71; Cos26; endothelial zinc finger protein induced by tumor necrosis factor alpha (EZFIT, ZNF71)

Function: - may be involved in transcriptional regulation Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 13 C2H2-type Zn⁺² fingers Compartment: nucleus (putative) Expression: - expressed in placenta > brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate & peripheral blood leukocytes - not detected in liver, lung, colon, stomach, salivary gland & thyroid gland - induced by tumor necrosis factor alpha (TNfalpha)

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 489 aa MW = 54 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 130-152 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 158-180 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 186-208 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 214-236 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 242-264 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 270-292 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 298-320 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 326-348 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 354-376 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 382-404 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 410-432 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 438-460 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 466-488 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 194545 UniProt Q9NQZ8 Pfam PF00096 Entrez Gene 58491 Kegg hsa:5849

References

UniProt :accession Q9NQZ8