zinc finger protein 653 (ZNF653, 67 kD zinc finger protein, zinc finger protein Zip67)

Function: 1) transcriptional repressor 2) represses NR5A1, PPARG, NR1H3, NR4A2, ESR1, NR3C1 transcriptional activity. 3) interacts with NR5A1. Structure: 1) belongs to the krueppel C2H2-type zinc-finger protein family 2) contains 5 C2H2-type zinc fingers Compartment: nucleus Expression: - expressed in testis, cerebellum, temporal lobe, hippocampus, adrenal > spleen, uterus, thymus, pancreas, kidney, stomach rectum

General

C2H2 type zinc finger protein nuclear protein

Properties

SIZE: MW = 67 kD entity length = 615 aa COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {107-118} MOTIF: arginine-rich region {115-118} MOTIF: arginine residue (SEVERAL) serine-rich region {195-207} MOTIF: serine residue (SEVERAL) alanine-rich region {218-225} MOTIF: alanine residue (SEVERAL) nuclear translocation signal {445-451} Zn finger C2H2-type SITE: 467-492 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 498-522 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 528-550 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 556-578 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 586-609 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q96CK0 Pfam PF00096

References

UniProt :accession Q96CK0