zinc finger protein 649 (ZNF649)

Function: 1) transcriptional repressor; KRAB domain is required for transcriptional repression 2) regulator of transcriptional factor complexes 3) suppresses SRE & AP1 transcription activities mediated by growth factor signaling pathways Structure: 1) belongs to the krueppel C2H2-type zinc-finger protein family 2) contains 10 C2H2-type zinc fingers 3) contains 1 KRAB domain Compartment: nucleus Expression: - expressed in heart, skeletal muscle, brain > liver, lung, kidney, pancreas, placenta - expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

General

C2H2 type zinc finger protein nuclear protein

Properties

SIZE: MW = 58 kD entity length = 505 aa COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 8-79 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 178-200 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 206-228 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 234-256 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 262-284 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 290-312 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 318-340 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 346-368 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 374-396 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 402-424 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 430-452 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9BS31 PFAM correlations

References

UniProt :accession Q9BS31