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zinc finger protein 638; cutaneous T-cell lymphoma-associated antigen se33-1; CTCL-associated antigen se33-1; nuclear protein 220; zinc finger matrin-like protein (ZNF638, NP220, ZFML)
Function:
- early regulator of adipogenesis
- transcription cofactor of CEBPs, controlling expression of PPARG & probably of other proadipogenic genes, such as SREBF1
- binds to cytidine clusters in double-stranded DNA
- interacts with FHL2
- interacts with CEBPA, CEBPD & CEBPG (putative)
Structure:
- contains 1 matrin-type Zn+2 finger
- contains 2 RRM domaind (RNA recognition motifd)
Compartment: nuclear, in nuclear speckles
Alternative splicing: named isoforms=5
Expression:
- broadly expressed
Pathology:
- isoform 5 is a tumor-associated antigen found in cutaneous T-cell lymphoma
- mycosis fungoides
- Sezary syndrome
Related
cutaneous T-cell lymphoma (CTCL)
General
DNA-binding protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1978 aa
MW = 221 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S128}
Ser phosphorylation site {S383}
Ser phosphorylation site {S420}
arginine-rich region {472-574}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S552}
Ser phosphorylation site {S605}
Ser phosphorylation site {S614}
RNP motif
NAME: RNP motif
SITE: 676-751
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 905-979
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
glutamate-rich region {1087-1355}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1100}
DNA-binding motif
SITE: 1353-1477
MOTIF: Ser phosphorylation site {S1401}
lysine-rich region {1580-1585}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S1667}
Ser phosphorylation site {S1882}
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 1928-1958
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 614349
UniProt Q14966
Entrez Gene 27332
Kegg hsa:27332
References
- UniProt :accession Q14966
- PMID: 8647861