Search
zinc finger protein 593; zinc finger protein T86 (ZNF593)
Function:
- negatively modulates the DNA binding activity of Oct-2 & thus its transcriptional regulatory activity
- could act either by binding to DNA octamer or by interacting with Oct-2
- may also be a modulator of other octamer-binding proteins
Structure:
- the protein is largely disordered, with the exception of the Zn+2 finger domain
- belongs to the ZNF593/BUD20 C2H2-type Zn+2-finger protein family
- contains 1 C2H2-type Zn+2 finger
Compartment: nucleus, nucleolus
Expression:
- ubiquitous
- detected in spleen, prostate, testis, small intestine, colon > thymus, peripheral blood leukocytes
General
C2H2 type zinc finger protein
nuclear protein
Properties
SIZE: entity length = 134 aa
MW = 15 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 61-85
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt O00488
Pfam PF12171
Entrez Gene 51042
Kegg hsa:51042
References
UniProt :accession O00488