zinc finger protein 589 (stem cell Zn+2 finger protein 1, ZNF589, SZF1)

Function: - may play a role in hematopoietic stem/progenitor cell differentiation - may play a role as a DNA binding-dependent transcriptional repressor - interacts with TRIM28 Structure: - KRAB domain mediates interaction with TRIM28 - belongs to the krueppel C2H2-type zinc-finger protein family - contains 4 C2H2-type zinc fingers - contains 1 KRAB domain Compartment: nucleus (putative) Alternative splicing: named isoforms=3 Expression: - isoform 2 is widely expressed. - isoform 3 is only expressed in CD34+ cells

General

C2H2 type zinc finger protein nuclear protein

Properties

SIZE: entity length = 364 aa MW = 41 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 35-108 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 248-270 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 276-298 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 304-326 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 332-354 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q86UQ0 PFAM correlations

References

UniProt :accession Q86UQ0