zinc finger protein 574 (ZNF574)

Function: - role in transcriptional regulation (putative) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 20 C2H2-type zinc fingers Compartment: nucleus Alternative splicing: named isoforms=2

General

C2H2 type zinc finger protein phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 99 kD entity length = 896 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 16-38 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 76-98 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 126-148 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S137} Ser phosphorylation site {S164} Zn finger C2H2-type SITE: 214-236 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 309-331 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 336-358 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 364-386 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 392-413 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 419-451 MOTIF: proline residue (SEVERAL) Zn finger C2H2-type SITE: 466-489 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 495-517 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 523-545 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 551-573 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 579-601 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 607-630 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 636-659 EFFECTOR-BOUND: Zn+2 alanine-rich region {657-733} MOTIF: alanine residue (SEVERAL) Zn finger C2H2-type SITE: 667-689 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T724} Ser phosphorylation site {S728} Zn finger C2H2-type SITE: 738-760 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 766-788 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 794-816 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 822-844 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q6ZN55 Pfam PF00096

References

UniProt :accession Q6ZN55