zinc finger protein 521 (early hematopoietic Zn+2 finger protein, LYST-interacting protein 3, ZNF521, EHZF, LIP3)

Function: - transcription factor that can both act as an activator or a repressor depending on the context - involved in BMP signaling & in the regulation of the immature compartment of the hematopoietic system - associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes - acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage, thus preventing EBF1 binding of DNA & activation of target genes - interacts with SMAD1 & SMAD4 Structure: - uses different DNA- & protein-binding zinc fingers to regulate the distinct BMP-Smad & hematopoietic system - belongs to the krueppel C2H2-type zinc-finger protein family - contains 30 C2H2-type zinc fingers Compartment: nucleus (putative) Expression: - predominantly expressed in hematopoietic cells - present in organs & tissues that contain stem & progenitor cells, myeloid &/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow & fetal liver - within the hematopoietic system, abundant in CD34+ cells but undetectable in mature peripheral blood leukocytes - levels rapidly decrease during the differentiation of CD34+ cells in response to hemopoietins Pathology: - chromosomal translocation t(9;18)(p13;q11.2) involving ZNF521 with PAX5 is found in acute lymphoblastic leukemia - translocation generates the PAX5-ZNF521 oncogene consisting of N-terminus of PAX5 & C-terminus of ZNF521

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 1311 aa MW = 148 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 47-67 EFFECTOR-BOUND: Zn+2 Breakpoint {72-73} Zn finger C2H2-type SITE: 118-140 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 146-168 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 174-196 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 202-224 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 246-269 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 281-304 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 310-332 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 405-429 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 437-460 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 477-500 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 513-536 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 560-585 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 634-656 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 664-686 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 694-717 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 722-745 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 752-775 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 783-805 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 809-832 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 886-908 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 930-952 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 959-981 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1020-1042 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1065-1083 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1138-1161 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1195-1217 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1225-1247 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1256-1279 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1286-1309 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q96K83 Pfam PF00096

References

UniProt :accession Q96K83