zinc finger protein 470 (chondrogenesis zinc finger protein 1, CZF-1, ZNF470, CZF1)

Function: - role in transcriptional regulation (putative) Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 17 C2H2-type zinc fingers - contains 1 KRAB domain Alternative splicing: named isoforms=2 Expression: - highly expressed in testis - very low expression in thymus - no expression in other tissues tested - expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 83 kD entity length = 717 aa COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 23-94 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 nuclear translocation signal {216-219} Zn finger C2H2-type SITE: 228-250 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 256-278 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 284-306 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 312-334 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 340-362 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 368-391 EFFECTOR-BOUND: Zn+2 MOTIF: nuclear translocation signal {385-388} Zn finger C2H2-type SITE: 397-419 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 425-447 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 453-475 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 481-503 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 509-531 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 537-559 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 565-587 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 593-615 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 621-643 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 649-671 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 677-699 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q6ECI4 PFAM correlations

References

UniProt :accession Q6ECI4