zinc finger protein 42 homolog (Zfp-42, reduced expression protein 1, REX-1, hREX-1, zinc finger protein 754, ZFP42, REX1, ZNF754)

Function: - role in self-renewal property of ES cells (By similarity). May be involved in transcriptional regulation Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 4 C2H2-type zinc fingers Compartment: nucleus Expression: - expressed in kidney, epidermal keratinocytes, epithelial cells (prostate, bronchii & small airways of lung) - expressed in embryonic stem cells - down-regulation upon retinoic acid addition to F9 stem cells Pathology: - expressed in malignant carcinoma cell lines - expressed in other carcinoma cell lines

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 35 kD entity length = 310 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 188-212 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 217-239 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 245-269 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 275-299 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q96MM3 Pfam PF00096

References

UniProt :accession Q96MM3