zinc finger protein 423; olf1/EBF-associated Zn+2 finger protein; hOAZ; smad- & Olf-interacting zinc finger protein (ZNF423, KIAA0760, OAZ)

Function: - transcription factor that can both act as an activator or a repressor depending on the context - role in BMP signaling & olfactory neurogenesis - associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes - acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neuron differentiation; interaction prevents EBF1 binding DNA & activation of olfactory-specific genes - involved in olfactory neurogenesis by participating in a developmental switch that regulates transition from differentiation to maturation in olfactory receptor neurons - controls proliferation & differentiation of neural precursors in cerebellar vermis formation - homodimer (putative) - interacts with PARP1 & EBF1 (putative) - interacts with SMAD1 & SMAD4 Structure: - uses different DNA- & protein-binding zinc fingers to regulate distinct BMP-Smad & Olf signaling pathways - C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 & SMAD4 - zinc fingers 28-30 mediate interaction with EBF1 - zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1 - zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs - belongs to the krueppel C2H2-type zinc-finger protein family - contains 30 C2H2-type zinc fingers Compartment: nucleus Expression: - expressed in brain, lung, skeletal muscle, heart, pancreas & kidney but not liver or placenta - also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney - within the adult brain, expressed in the substantia nigra, medulla, amygdala, thalamus & cerebellum

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 1284 aa MW = 145 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 67-93 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 138-160 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 166-188 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 194-216 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 222-244 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 263-286 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 295-318 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 323-345 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 409-433 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 441-464 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 480-503 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 517-540 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 563-588 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S599} Ser phosphorylation site {S604} Ser phosphorylation site {S608} Zn finger C2H2-type SITE: 632-654 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 662-684 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 692-715 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 720-743 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 750-773 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 781-803 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 807-830 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 886-908 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 930-952 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 959-981 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1020-1042 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1064-1082 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1120-1143 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1168-1190 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1198-1220 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1229-1252 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1259-1282 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604557 UniProt Q2M1K9 Pfam PF00096 Entrez Gene 23090

References

UniProt :accession Q2M1K9