zinc finger protein 415 (ZNF415)

Function: - role in transcriptional regulation - transcriptional activity differs among the various isoforms - all isoforms except isoform 3 seem to suppresst transcriptional activities of AP-1 & p53 Structure: contains 12 C2H2-type zinc fingers Compartment: - nucleus, cytoplasm - isoforms 1, 2, 4 & 5 show both nuclear & cytoplasmic localization - isoform 3 localizes only to nucleus Alternative splicing: named isoforms=5 Expression: - expressed in all tissues examined - isoforms are differentially expressed - isoform 3 & 5 > isoform 4 > isoform 2 >isoform 1

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 69 kD entity length = 603 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Zn finger C2H2-type SITE: 264-286 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 292-314 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 320-342 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 348-370 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 376-398 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 404-426 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 432-454 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 460-482 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 488-510 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 516-538 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 544-566 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 572-594 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q09FC8 Pfam PF00096 Entrez Gene 55786

References

UniProt :accession Q09FC8