zinc finger protein 41 (ZNF41)

Function: - may be involved in transcriptional regulation Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 18 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (putative) Alternative splicing: - named isoforms=8 - additional isoforms seem to exist Expression: - expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas Pathology: - defects in ZNF41 are the cause of non-syndromic mental retardation X-linked type 89 - chromosomal translocation t(X;7)(p11.3;q11.21) involving ZNF41 has been found in a patient with severe mental retardation.

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 821 aa MW = 94 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 69-140 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 313-335 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 341-364 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 369-391 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 397-419 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 425-447 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 453-475 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 481-503 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 509-531 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 537-559 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 565-587 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 593-615 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 621-643 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 649-671 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 677-699 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 705-727 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 733-755 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 761-783 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 789-811 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 314995 MORBIDMAP 314995 UniProt P51814 PFAM correlations Entrez Gene 7592 Kegg hsa:7592