Search
zinc finger protein 40; Human immunodeficiency virus type I enhancer-binding protein 1; HIV-EP1; major histocompatibility complex-binding protein 1; MBP-1; positive regulatory domain II-binding factor 1; PRDII-BF1 (HIVEP1, ZNF40)
Function:
- specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters including those of SV40, CMV, & HIV1
- related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, & interferon-beta genes
- may act in T-cell activation
Structure:
- contains two sets of 2 Zn+2-fingers, which are widely separated & recognize the same DNA sequence
- there is a fifth Zn+2-finger in-between
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: induced by mitogens & phorbol ester
General
C2H2 type zinc finger protein
DNA-binding protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 2717 aa
MW = 297 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 406-428
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 434-456
EFFECTOR-BOUND: Zn+2
serine-rich region {803-806}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 958-981
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1050}
Ser phosphorylation site {S1872}
Ser phosphorylation site {S1873}
Zn finger C2H2-type
SITE: 2087-2109
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 2115-2139
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 194540
UniProt P15822
Pfam PF00096
Kegg hsa:3096
References
UniProt :accession P15822