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zinc finger protein 396; zinc finger & SCAN domain-containing protein 14 (ZNF396, ZSCAN14)
Function:
- isoforms 1 & 2 act as DNA-dependent transcriptional repressors
- isoforms 1 & 2 can for homodimers or heterodimers
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
- contains 1 SCAN box domain
Compartment:
- isoform 1: nucleus
- isoform 2: nucleus, cytoplasm
Alternative splicing: named isoforms=3
Expression:
- expressed in liver > skeletal muscle > kidney, pancreas, spleen, prostate
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 335 aa
MW = 39 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: scan box (LeR) {52-134}
MOTIF: leucine residue (SEVERAL)
Zn finger C2H2-type
SITE: 251-273
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 279-301
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 307-329
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 609600
UniProt Q96N95
Pfam PF02023
Entrez Gene 252884
Kegg hsa:252884
References
- UniProt :accession Q96N95
- Entrez Gene :accession 252884