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zinc finger protein 384; CAG repeat protein 1; CAS-interacting zinc finger protein; nuclear matrix transcription factor 4; nuclear matrix protein 4; trinucleotide repeat-containing gene 1 protein (ZNF384, CAGH1, CIZ, NMP4, TNRC1)
Function:
- transcription factor
- binds the consensus DNA sequence [GC]AAAAA
- seems to bind & regulate the promoters of MMP1, MMP3, MMP7 & COL1A1 (putative)
- interacts with BCAR1 (putative)
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 8 C2H2-type Zn+2 fingers
Compartment: nucleus (putative)
Alternative splicing:
- named isoforms=3
- additional isoforms seem to exist
Pharmacology:
- ZNF384 is a potential therapeutic target for psoriasis* & Alzheimer's disease* by regulating PPARG, ZNF415, HLX,& ANHX [3]
* see disease interactions of psoriasis with Alzheimer's disease
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 577 aa
MW = 63 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S214}
Zn finger C2H2-type
SITE: 228-250
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 256-278
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 284-306
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 317-339
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 345-367
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 373-397
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 403-425
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 433-455
EFFECTOR-BOUND: Zn+2
glutamine-rich region {461-521}
MOTIF: glutamine residue (SEVERAL)
alanine-rich region {466-499}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 609951
UniProt Q8TF68
Pfam PF00096
Entrez Gene 171017
Kegg hsa:171017
References
- UniProt :accession Q8TF68
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/ZNF384ID42881ch12p13.html
- Liu S, Yuan X, Su H et al
ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer's
Disease Through Inflammation and Metabolism.
Front Immunol. 2022 May 20;13:892368
PMID: 35669784 PMCID: PMC9163351 Free PMC article