zinc finger protein 366 (ZNF366)

Function: - transcriptional repressor - acts as corepressor of ESR1 - seems to involve CTBP1 & histone deacetylases - interacts with ESR1, NRIP1 & CTBP1 Structure: contains 11 C2H2-type Zn⁺² fingers Compartment: nucleus

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 744 aa MW = 85 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 253-275 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 281-303 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 309-331 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 337-359 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 365-387 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 393-415 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 421-443 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 449-471 EFFECTOR-BOUND: Zn+2 NRIP1 interaction {455-744} MOTIF: Zn finger C2H2-type SITE: 477-499 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 505-527 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 533-556 EFFECTOR-BOUND: Zn+2 CTBP1 interaction {558-744}

Database Correlations

OMIM 610159 UniProt Q8N895 Pfam PF00096 Entrez Gene 167465 Kegg hsa:167465