zinc finger protein 354C; kidney, ischemia, & developmentally-regulated protein 3; hKID3 (ZNF354C, KID3)

Function: - role as transcription repressor (putative) - suppresses osteogenic effects of RUNX2 - binds to 5'-CCACA-3' core sequence - role in osteoblastic differentiation (putative) - interacts with RUNX2 - binds consensus element OSE2 Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 11 C2H2-type zinc fingers involved in nuclear targeting & DNA-binding - contains 1 KRAB domain, not required for nuclear targeting or for DNA binding Compartment: nucleus Expression: - expressed in kidney & skeletal muscle - very low expression in brain & heart - during development, expressed in brain with very low expression in lung & liver

General

DNA-binding protein transcriptional silencer (transcriptional repressor) zinc finger protein

Properties

SIZE: MW = 65 kD entity length = 554 aa COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 12-83 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 216-238 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 244-266 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 272-294 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 300-322 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 328-350 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 356-378 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 384-406 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 412-434 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 440-462 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 468-490 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 496-518 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q86Y25 PFAM correlations Entrez Gene 30832

References

UniProt :accession Q86Y25